Relationship between heart rate variabiliyt and chronic complications in patients with type 2 diabetes mellitus

Abstract

Objective To investigate the relationship between heart rate variability （ HRV） and chronic complications in pa-tients with type 2 diabetes mellitus （T2DM）.Methods A total of 96 patients with T2DM was given chronic complication assessment . Demographic data were obtained .Diabetic retinopathy , diabetic kidney disease , diabetic peripheral neuropathy （ DPN） , and peripher-al artery disease （ PAD） were diagnosed according to international clinical classification .The parameters of HRV in the patients with diabetes and non-diabetes were examined with24 h Holter recorder .Results The HRV parameters of type 2 diabetic patients were significantly lower than those of non-diabetes （ P 〈0.05 ） .HRV time domain parameters [ standard deviation of normal RR intervals （SDNN）, standard deviation of 5-minute mean RR intervals （SDANN）, root mean square difference among successive RR normal in-tervals （ RMSSD） ] were especially impaired in diabetic patients with retinopathy compared to those without retinopathy .HRV parame-ters except low-to-high frequency ratio （ LF/HF） and MNN were lower in diabetic patients with kidney disease than those without kid-ney disease .HRV parameters were no significant difference between patients with or without PAD .Conclusions HRV of diabetic pa-tient is lower.Diabetic retinopathy and kidney disease impact on the HRV . Key words: Diabetes mellitus, type 2 ; Diabetic nephropathies ; Diabetic neuropathies ; Diabetic retinopathy ; Diabetic angiopa-thies; Heart rate; Autonomic nervous system/physiopathology