Relationship between heart failure with preserved ejection fraction and thyroid disorders: Review of the Literature

Abstract

Introduction: Heart failure with preserved ejection may be combined with some other disease or as a result of dysfunction in their normal performance. Thyroid dysfunctions and abnormal hormone levels may be in close relation with problems, and may be indicators of future failure. Methods: Scopus and PubMed were searched methodically using thyroid and heart failure with preserved ejection fraction as search terms on April 2015 to find articles with English language in which the association between disorders and failure with preserved ejection (HFPEF) had been evaluated. Full text of all relevant articles was comprehensively reviewed and used for data extraction. Results: Of total 51 articles found in PubMed, 34 records found in Scopus and 3 articles found through reference list screening, only 13 papers fully met the inclusion criteria for further assessment. A total of 2135 patients participated in the included literatures, 1450 were male and 595 were female. Discussion: Results of studies show that cardiac and functions are in close relationship, in which the level of hormone, predominantly T3 level can be considered as an independent prognostic factor in HFPEF. Moreover, findings suggested that hormones level can be considered as predictors for mortality due to HF. Conclusion: Based on the results obtained in the included documents, there may be association between disorders and hormone levels with cardiac complications, particularly failure with preserved ejection fraction.