Abstract
The possible relationship between growth hormone (GH) responses to the dopamine (DA) agonist apomorphine (APO; 0.24 mg i.v.) and CSF concentrations of the monoamine metabolites was investigated in 15 patients with dementia of the Alzheimer type (DAT). A significant negative correlation was found between the CSF concentrations of homovanillic acid (HVA) and the maximum APO-stimulated serum GH levels. Assuming that CSF HVA reflects central DA release and the GH response to APO reflects postsynaptic DA D<sub>2</sub> receptor function, this finding suggests that low DA release is associated with upregulation of DA D<sub>2</sub> in DAT.
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