Abstract

Background: The relationship between growth hormone (GH) and cytokines remains unclear. Several studies have suggested that GH increases tumor necrosis factor (TNF)-α production in both children and adults. However, a number of studies have demonstrated a negative correlation between GH and TNF α. The aim of this study is to explore the relationship between endogenous GH secretion and certain pro and anti-inflammatory cytokines in short children undergoing GH stimulation testing for evaluation for GH deficiency. Methods: Plasma growth hormone, TNF α, CRP, IL-6, IL1-β, IL-4 and IL-10 levels are obtained at baseline and every 30 minutes for 150 minutes following two provocative agents (clonidine, and either arginine or glucagon). Results: Among the 23 children, 7 are found to be GH deficient. No significant differences in baseline TNF α levels are found between GH deficient and GH sufficient children. No correlation is identified between TNF α levels and GH levels during stimulation testing. Furthermore, no relationship is found between GH and pro-inflammatory cytokines or GH and anti-inflammatory cytokines. Conclusion: Our results do not demonstrate an acute relationship between endogenous GH secretion and the cytokines examined.

Highlights

  • Increasing evidence in the literature supports an interaction between the immune system and the growth hormone (GH)/Insulin likeHow to cite this paper: Tafuri, K., Dixon, D., Markarian, K., Lane, A. and Wilson, T.A. (2015) Relationship between Growth Hormone and Cytokines in Short Children Undergoing Growth Hormone Stimulation Testing

  • Samples were obtained for GH, tumor necrosis factor (TNF) α (#Y5000000DH), CRP, IL-6, IL1-β, IL-4 and IL-10 at baseline, and at 30, 60, 90, 120 and 150 minutes following stimulation with clonidine and either arginine or glucagon when arginine could not be obtained

  • One child underwent GH stimulation testing after adult height was achieved to identify if GH was indicated

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Summary

Introduction

Increasing evidence in the literature supports an interaction between the immune system and the GH/Insulin likeHow to cite this paper: Tafuri, K., Dixon, D., Markarian, K., Lane, A. and Wilson, T.A. (2015) Relationship between Growth Hormone and Cytokines in Short Children Undergoing Growth Hormone Stimulation Testing. (2015) Relationship between Growth Hormone and Cytokines in Short Children Undergoing Growth Hormone Stimulation Testing. The GH receptor is a member of the type 1 cytokine receptor family and is expressed on human peripheral blood mononuclear cells. The presence of both GH and IGF-1 receptors on different lymphocyte subpopulations suggests a role for the GH/IGF-1 axis in immune function [4]. Several studies have suggested that GH increases tumor necrosis factor (TNF)-α production in both children and adults. The aim of this study is to explore the relationship between endogenous GH secretion and certain pro and anti-inflammatory cytokines in short children undergoing GH stimulation testing for evaluation for GH deficiency. Conclusion: Our results do not demonstrate an acute relationship between endogenous GH secretion and the cytokines examined

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