Abstract
Objective To expolre the relationshio between genetic polymorphisms of quinone oxidoreductase 1 (NQO1) and susceptibility and chenosensitivity of breast cancer.Methods Totally 162 breast cancer patients and 190 non-cancer female controls were selected.The breast cancer patients were treated with TC and FEC chemotherapy.The genotypes were detected by using TaqMan-MGB probe-based real time quantitive polymerase chain reaction technology method.Results The risk of breast cancer was decreased in NQO1rs1800566 C genetic carrier [odds ratio (OR) =0.60,95％ confidence interval (CI) =0.37-0.97],compared with the controls.NQO1rs1800566 TT was the high risk genotype.The RR of C genetic carrier in NQO1rs1800566 cases was64.9％,which was significantly higher than that of the TT genotype.Among the cased administrated with TC regimens,the RR of CT genotype in NQO1rs1800566 cases was 71.0％,which was singificantly higher than that of the TT genotype.Conclusion The results indicated that the polymorphisms in NQO1 genes,which might be associated with breast cancer risk of Chinese women. Key words: Quinone oxidoreductase 1 ; Single nucleotide polymorphism; Breast carcinoma; Chemotherapeutic effect
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