Relationship between Gastroesophageal Reflux and IL-8

Abstract

Abstract Background Gastroesophageal reflux disease (GERD) is a condition that develops by reflux of the stomach contents into the esophagus, and causes troublesome symptoms, such as heartburn and regurgitation. Aim of the work to evaluate the serum level of IL-8 in patients of GERD with its degrees including NERD and refractory GERD and normal controls. Patients and Methods The study included four groups of patients, Group-1 including 15 patients with GERD symptoms who didn’t receive treatment or who received treatment for less than 8 weeks with improvement of symptoms, Group-2 including 15 Patients with NERD, group-3 including 15 patients with refractory GERD and who received PPIs for more than 8 weeks without improvement of symptoms and group-4 of normal controls. Results serum IL8 level was elevated in the group of refractory GERD more than the group of GERD more than the group of NERD more than normal controls. Relation between serum IL8 and pathological findings in each group included in the study revealed statistically significant difference, in the group of GERD IL8 was elevated in the cases of severe reflux oesophagitis more than mild reflux oesophagitis more than moderate reflux oesophagitis more than barrets esophagitis, there is statistically significant difference. While in patients with refractory GERD IL8 was elevated in the cases of severe oesophagitis more than the cases of moderate reflux oesophagitis, there is statistically not significant difference Conclusion Serum Interleukin-8 (IL8) level was elevated in patients with refractory GERD more than patients with GERD more than patients of NERD more than normal controls. Pathological features that we found in patients with GERD were moderate reflux oesophagitis (52%) more than mild reflux oesophagitis (40%) more than severe reflux oesophagitis (8%), while in patients with refractory GERD there were severe reflux oesophagitis (56%) more than Barrett's esophagitis (28%) more than moderate reflux oesophagitis (16%).