Relationship Between Gallbladder Bile Concentration and Motility in Conscious Dogs: Role of Cholecystokinin

Abstract

Muramatsu, S., K. Sonobe, A. Mizumoto, T. Yamada and Z. Itoh. Relationship between gallbladder bile concentration and motility in conscious dogs: Role of cholecystokinin. Peptides 18(1) 111–118, 1997.—The relationship between gallbladder (GB) bile concentration and motility was studied in conscious dogs. The 12-h GB bile concentrations between meals could be divided into three periods: diluting, minimum, and concentrating periods. During the diluting period, inhibition of GB contractions by a CCK A receptor antagonist, atropine or hexamethonium, resulted in concentration of GB bile, whereas during the concentrating period, CCK-8 shifted the concentration process back to dilution. The GB appears to absorb water continuously from GB bile, which is not regulated by cholinergic or CCK A receptors. The postprandial progressive dilution of GB bile is brought about by GB pumping controlled by cholecystokinin (CCK).