Relationship between fibroblastic foci profusion and high resolution CT morphology in fibrotic lung disease

Simon L F Walsh,Andrew G Nicholson,Thomas V Colby,Athol U Wells,Samuel A Yousem,Anand Devaraj,Nicola Sverzellati,Jan Von Der Thüsen,David M Hansell

doi:10.1186/s12916-015-0479-0

Abstract

BackgroundFibroblastic foci profusion on histopathology and severity of traction bronchiectasis on highresolution computed tomography (HRCT) have been shown to be predictors of mortality in patients with idiopathic pulmonary fibrosis (IPF). The aim of this study was to investigate the relationship between fibroblastic foci (FF) profusion and HRCT patterns in patients with a histopathologic diagnosis of usual interstitial pneumonia (UIP), fibrotic non-specific interstitial pneumonia (NSIP) and chronic hypersensitivity pneumonitis (CHP).MethodsThe HRCT scans of 162 patients with a histopathologic diagnosis of UIP or fibrotic NSIP (n = 162) were scored on extent of groundglass opacification, reticulation, honeycombing, emphysema and severity of traction bronchiectasis. For each patient, a fibroblastic foci profusion score based on histopathologic appearances was assigned. Relationships between extent of fibroblastic foci and individual HRCT patterns were investigated using univariate correlation analysis and multivariate linear regression.ResultsIncreasing extent of reticulation (P < 0.0001) and increasing severity of traction bronchiectasis (P < 0.0001) were independently associated with increasing FF score within the entire cohort. Within individual multidisciplinary team diagnosis subgroups, the only significant independent association with FF score was severity of traction bronchiectasis in patients with idiopathic pulmonary fibrosis (IPF)/UIP (n = 66, r2 = 0.19, P < 0.0001) and patients with chronic hypersensitivity pneumonitis (CHP) (n = 49, r2 = 0.45, P < 0.0001). Furthermore, FF score had the strongest association with severity of traction bronchiectasis in patients with IPF (r2 = 0.34, P < 0.0001) and CHP (r2 = 0.35, P < 0.0001). There was no correlation between FF score and severity of traction bronchiectasis in patients with fibrotic NSIP. Global disease extent had the strongest association with severity of traction bronchiectasis in patients with fibrotic NSIP (r2 = 0.58, P < 0.0001).ConclusionIn patients with fibrotic lung disease, profusion of fibroblastic foci is strikingly related to the severity of traction bronchiectasis, particularly in IPF and CHP. This may explain the growing evidence that traction bronchiectasis is a predictor of mortality in several fibrotic lung diseases.

Highlights

Fibroblastic foci profusion on histopathology and severity of traction bronchiectasis on highresolution computed tomography (HRCT) have been shown to be predictors of mortality in patients with idiopathic pulmonary fibrosis (IPF)
To date no attempts have been made to determine whether a relationship exists between fibroblastic foci profusion and HRCT patterns; the aim of this study is to determine if fibroblastic foci profusion is linked to any individual HRCT pattern
Exclusions were due to 1) no multidetector HRCT data available (n = 133), 2) HRCT study performed more than 3 months before or after the data of the surgical lung biopsy (n = 20) and 3) histopathologic diagnosis assigned was not usual interstitial pneumonia (UIP), fibrotic non-specific interstitial pneumonia (NSIP) or chronic hypersensitivity pneumonitis (CHP) (n = 23)

Summary

Introduction

Fibroblastic foci profusion on histopathology and severity of traction bronchiectasis on highresolution computed tomography (HRCT) have been shown to be predictors of mortality in patients with idiopathic pulmonary fibrosis (IPF). The aim of this study was to investigate the relationship between fibroblastic foci (FF) profusion and HRCT patterns in patients with a histopathologic diagnosis of usual interstitial pneumonia (UIP), fibrotic non-specific interstitial pneumonia (NSIP) and chronic hypersensitivity pneumonitis (CHP). High resolution computed tomography (HRCT) plays an integral part in the evaluation of patients with diffuse lung diseases, and several studies have reported on the prognostic significance of several HRCT patterns including honeycombing [1, 2, 18,19,20] and, more recently, traction bronchiectasis [4,5,6, 18, 21, 22]. Patients with histopathologic confirmation of UIP, fibrotic NSIP and CHP were included in the study in order to capture a full range of fibroblastic foci profusion

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