Abstract
ABSTRACTObjective: To evaluate the fiber intake and the relationship with cardiovascular risk factors in adolescents with juvenile systemic lupus erythematosus.Methods: This is a cross-sectional in which adolescents with juvenile systemic lupus erythematosus were evaluated. The dietary consumption was assessed by the 24-hour recall; nutritional status was classified according to the Body Mass index/Age by Sex; abdominal obesity was assessed through waist circumference, waist-to-height ratio and glucose and lipid metabolism. The data were analyzed using Statistical Software for Professionals 14 and all statistical analyses used an alpha error of 5%.Results: 52 patients were evaluated, with a mean age of 16.7±1.5 years. Inadequate fiber consumption occurred in 61.5% (n=32) of them. Average of waist circumference measures (81.4 vs. 75.5 cm; p=0.02), waist-to-height ratio (0.51 vs. 0.47; p=0.02) and systolic blood pressure (122.1 vs. 114.8 mmHg; p=0.03) were higher in those who had inadequate fiber intake. Among the cardiovascular risk factors evaluated, the waist/height ratio showed a significant negative correlation with fiber consumption (r=-0.3; p=0.04), that is, the higher the fiber consumption, the lower the value of the waist ratio /stature.Conclusions: Low dietary fiber intake in adolescents with systemic lupus erythematosus juvenile is related to higher abdominal adiposity and consequently with increased cardiovascular risk.
Highlights
Juvenile systemic lupus erythematosus (JSLE) is a chronic, multisystemic inflammatory disease
The pattern of dyslipidemia (DLP) in JSLE is characterized by high levels of triglycerides (TG) and very low density lipoproteins (VLDL), associated with lower levels of high density lipoprotein (HDL), which demonstrates that JSLE itself promotes conditions that are favorable to the atherogenic inflammatory process.[3,4]
Our study found that a minority of patients had adequate fiber intake, which can be harmful, since fibers reduce glycemia and lipid absorption and contribute to the prevention and treatment of obesity.[21]
Summary
Juvenile systemic lupus erythematosus (JSLE) is a chronic, multisystemic inflammatory disease. Autoimmunity, the inflammatory process of JSLE and the use of several drugs are directly related to changes in the lipid profile and the metabolism of lipoproteins in the disease, both in the active and remission phases. The pattern of dyslipidemia (DLP) in JSLE is characterized by high levels of triglycerides (TG) and very low density lipoproteins (VLDL), associated with lower levels of high density lipoprotein (HDL), which demonstrates that JSLE itself promotes conditions that are favorable to the atherogenic inflammatory process.[3,4] Some classes of drugs, especially corticosteroids, can induce changes in nutritional status (NS) and obesity, systemic arterial hypertension (SAH), DLP, hyperinsulinemia and insulin resistance (IR).[5]
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