Abstract
Objective Investigate the relationship between gross tumor volume (GTV)-related factors including GTV-T volume, the maximum thickness of the esophageal lesion plane and GTV-T volume/length(GTV-T volume divided by the length of the lesion calculated by the number of GTV-T layers) and the locoregional failure of radical intensity-modulated radiation therapy (IMRT) for esophageal carcinoma. Methods A total of 133 patients with esophageal cancer undergoing radical IMRT were enrolled. The factors related to GTV-T including GTV-T volume, the maximum thickness of the esophageal lesions, GTV-T volume/length were calculated. The relationship between GTV-T related factors and local recurrence of tumors was retrospectively analyzed. Results There was positively linear association between the locoregional failure rate of GTV-T and the volume of GTV-T. The volume of GTV-T tumor was 36 cm3, the maximum wall thickness was 2.5 cm, and the GTV-T volume/length was calculated as 5.3 cm2. These critical values could be utilized to predict the risk of locoregional failure of IMRT for esophageal carcinoma. Conclusions The GTV-T factors can be adopted to predict the local control and the risk of locoregional failure of radical IMRT for esophageal carcinoma to certain extent. Key words: Esophageal carcinoma/radiotherapy; Intensity-modulated radiation therapy; Gross tumor volume; Wall thickness
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