Abstract
Objective Investigate the relationship between gross tumor volume (GTV)-related factors including GTV-T volume, the maximum thickness of the esophageal lesion plane and GTV-T volume/length(GTV-T volume divided by the length of the lesion calculated by the number of GTV-T layers) and the locoregional failure of radical intensity-modulated radiation therapy (IMRT) for esophageal carcinoma. Methods A total of 133 patients with esophageal cancer undergoing radical IMRT were enrolled. The factors related to GTV-T including GTV-T volume, the maximum thickness of the esophageal lesions, GTV-T volume/length were calculated. The relationship between GTV-T related factors and local recurrence of tumors was retrospectively analyzed. Results There was positively linear association between the locoregional failure rate of GTV-T and the volume of GTV-T. The volume of GTV-T tumor was 36 cm3, the maximum wall thickness was 2.5 cm, and the GTV-T volume/length was calculated as 5.3 cm2. These critical values could be utilized to predict the risk of locoregional failure of IMRT for esophageal carcinoma. Conclusions The GTV-T factors can be adopted to predict the local control and the risk of locoregional failure of radical IMRT for esophageal carcinoma to certain extent. Key words: Esophageal carcinoma/radiotherapy; Intensity-modulated radiation therapy; Gross tumor volume; Wall thickness
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.