Abstract
The regulation of Na+ in alveolar cells is important for maintaining lung fluid homeostasis and, therefore, lung function. We explored the relationship between the amount of Na+ in exhaled breath condensate (EBC) and DLCO and the components of DLCO, alveolar‐capillary membrane conductance (DM), and pulmonary capillary blood volume (Vc). We recruited 26 subjects (age=28±9yrs., ht.=173±11cm., wt.=71±13kg, body surface area (BSA)=1.8±0.2m2, FVC=97±15%, FEV1=95±14%, FEF25‐75=92±24% predicted, mean±SD) and collected EBC for 25 min. along with measures of DLCO, DM and Vc. The volume of EBC was 3.8±0.8ml, EBC Na+ was 2.7±1.7mmol/l, DLCO was 23±6ml/min/mmHg, DM was 35±9ml/min/mmHg, Vc was 58±26ml, mean±SD. There was a relationship between EBC volume and DLCO and DM (r=0.47 and 0.57, respectively, p<0.05). There was a positive correlation between DLCO, DM, Vc and EBC volume with BSA (r=0.76, 0.68, 0.69, and 0.42, respectively, p<0.05), a positive relationship between EBC Na+ and DLCO, DM and Vc (r=0.48, r=0.39, r=0.52, respectively, p<0.05) and a negative correlation between EBC Na+ and DM corrected for Vc (DM/Vc, r= −0.36, p=0.074). These results suggest that EBC volume and EBC Na+ are related to DLCO, DM, and Vc but that this is likely related to body size. EBC Na+ is inversely related to DM/Vc possibly suggesting EBC Na+ may be a surrogate measure of lung water.
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