Abstract
Gross cystic breast disease is a common condition. Women with apocrine breast cysts may be at higher risk of breast cancer than women with cysts which are lined by flattened epithelium. Apocrine cysts have been shown to be associated with higher intracystic levels of dehydroepiandrosterone sulphate and intracystic sodium to potassium ratios of less than 3. In this study we measured the concentrations of epidermal growth factor, dehydroepiandrosterone and its sulphate in breast cyst fluid. The concentrations of all three analytes were significantly higher in cysts with intracystic Na+/K+ ratios of less than 3 than in cysts with electrolyte ratios of greater than or equal to 3 (P less than 0.001). The higher levels of EGF in cysts with low intracystic electrolyte ratios may provide an explanation of why women with apocrine cysts may be at greater risk of breast cancer. Positive correlations were obtained between concentrations of EGF and DHAS and between EGF and DHA, compatible with the view that intracystic EGF levels may be androgen-modulated. A positive correlation was also obtained between DHA and DHAS concentrations which supports the view that DHA in cyst fluid may be derived from the metabolism of DHAS in the breast cyst wall.
Highlights
Gross cystic breast disease is a common condition affecting about 7% of women in the western world (Haagensen et al, 1981)
Dixon et al (1983) have shown that these cysts can be divided into two groups according to breast cyst fluid sodium to potassium ratios, namely, Na+/K+ 3
Women with apocrine breast cysts may be at a higher risk of subsequent development of breast cancer than women with cysts which are lined by flattened epithelium (Haagensen et al, 1981; Dixon et al, 1985)
Summary
Gross cystic breast disease (cysts more than 3 mm in diameter) is a common condition affecting about 7% of women in the western world (Haagensen et al, 1981). Dixon et al (1983) have shown that these cysts can be divided into two groups according to breast cyst fluid sodium to potassium ratios, namely, Na+/K+ 3 (cysts lined by flattened epithelium). Women with apocrine breast cysts may be at a higher risk of subsequent development of breast cancer than women with cysts which are lined by flattened epithelium (Haagensen et al, 1981; Dixon et al, 1985)
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