Abstract
The results of this study provide direct evidence for the synthesis of F-prostaglandins in the uterine endometrium in response to parenteral administration of bacterial endotoxin. This finding, together with indirect evidence on similarities in response of pregnant mice to either endotoxin or PGF 2 α and the effects on this response of agents which block prostaglandin action or synthesis, lead us to conclude that the abortifacient action of endotoxin is mediated by PGF 2 α . The data suggest that diarrhea produced by endotoxin is also a manifestation of prostaglandin synthesis, probably by cells in the intestinal mucosa. The finding of large amounts of PGF or its metabolites in the urine of male as well as pregnant female mice implies that endotoxemia evokes a generalized synthesis of F-prostaglandins. Intrauterine fetal death appears not to be due to a direct effect of prostaglandin on the uterus, but to the effect of other substances (possibly serotonin) released by endotoxin or exogenous prostaglandin.
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