Relationship between elevated impulsivity and cognitive declines in elderly community-dwelling individuals

Keisuke Sakurai,Nobutaka Masuoka,Haowei Li,Noriko Inamura,Tatsuhiro Hisatsune

doi:10.1038/s41598-020-78124-5

Keisuke Sakurai, Nobutaka Masuoka + Show 3 more

Open Access

https://doi.org/10.1038/s41598-020-78124-5

Copy DOI

Journal: Scientific Reports	Publication Date: Dec 1, 2020
Citations: 14	License type: open-access

Affiliation: The University of Tokyo, Mitsui (Japan)

Abstract

Impulse control disorders are recognized as one of the behavioral and psychological symptoms of dementia (BPSD). Majority of studies on the treatment of BPSD related to impulsivity have rather focused on the aggression and agitation. In particular, it has not been investigated how cognitive declines are associated with impulsivity in community-dwelling elderly people. Here, we have measured the cognitive and memory functions and impulsivity of 212 elderly community-dwelling people using a psychometric test battery and analyzed the correlation between their level of impulsivity and cognitive functions by multiple regression analysis. We found an elevation of impulsivity, which was evaluated by the Barratt Impulsiveness Scale-11, closely related to decline of cognitive functions, which were evaluated by the Montreal Cognitive Assessment and the Mini-Mental State Examination, and Logical Memory function, which were evaluated by the Wechsler Memory Scale-Delayed Recall. Then we have divided them into groups based on the severity of cognitive decline and conducted an analysis of each group, the result of which showed that as this tendency was particularly noticeable in the suspected dementia group. Therefore, we have concluded that heightened impulsivity is negatively associated with cognitive and memory functions in community-dwelling elderly people.

Highlights

Impulse control disorders are recognized as one of the behavioral and psychological symptoms of dementia (BPSD)
SE β p on human impulsivity is provided by studies on dopamine-related changes in patients who have Parkinson’s disease (PD) such as the observation of behavioral changes that meet the criteria for impulse control disorders in some of PD patients following the administration of dopamine replacement t herapies[40]
Multiple linear regression was used to examine the relation between Montreal Cognitive Assessment (MoCA) score and the Barratt Impulsiveness Scale (BIS)-11 score with several covariates

Summary

Introduction

Impulse control disorders are recognized as one of the behavioral and psychological symptoms of dementia (BPSD). In AD patients, first symptoms take the form of mild cognitive impairment, in which memory loss is the main symptom While their daily lives are still unaffected at the first stage of AD16,17, impulsivity may be elevated in a particular percentage (17–40%) of AD p atients[18,19]. On human impulsivity is provided by studies on dopamine-related changes in patients who have Parkinson’s disease (PD) such as the observation of behavioral changes that meet the criteria for impulse control disorders in some of PD patients following the administration of dopamine replacement t herapies[40] It has been reported in rat studies as well that the enhanced dopamine neurotransmission increases the number of impulsive actions, which is one of key indicators of impulsivity, while those impulsive responses are suppressed by decreased dopaminergic neurotransmission[41,42]. In Japan, Kobashi and Ida have translated BIS-11 into Japanese[48], and internal consistency, retest reliability, and construct validity of the Japanese version of the BIS-11 have been c onfirmed[49]

Objectives

Methods

Results

Conclusion