Relationship between electrokinetic parameters of red blood cells and acute coronary syndrome

Abstract

Aim. To assess the state of electrokinetic properties of red blood cells in different variants of the course of acute coronary syndrome (ACS).
 Materials and methods. The study deals with the assessment of clinical and laboratory-instrumental data from 201 patients with ACS, the results of electrokinetic parameters of red blood cells, their predictors.
 Results. According to electrokinetic indices of erythrocytes, no reliable differences between the groups were found out. The mean red blood cell oscillation amplitude (MRBCOA) in group 1 was 1.83 ± 0.05, in group 2 – 1.75 ± 0.06 (t = 0.955, p = 0.341). Stationary red blood cell percentage (SRBCP) in patients with NSTE-ACS was 15.6 ± 1.45, in patients with STE-ACS – 13.54 ± 1.64 (t = 0.957, p = 0.339). The methods of multiple disperse and regressive analysis were used. Predictors of SRBCP indices in NSTE-ACS group appeared to be intima-media complex thickness (IMCT), left ventricle diastolic dysfunction, coronary insufficiency index (CII); in STE-ACS group – IMCT, MRBCOA, troponin I and AST levels. In STE-ACS group, predictors of MRBCOA were SRBCP and troponin I level, in NSTE-ACS – no predictors, influencing MRBCOAwere revealed.
 Conclusions. In NSTE-ACS group, the following predictors, influencing SRBCP were detected:IMCT, CII, LV diastolic dysfunction. In patients of STE-ACS group, there were found the predictors, influencing electrokinetic properties of red blood cells: IMCT, AST, troponin I. In acute coronary syndrome, changes in electrokinetic parameters of red blood cells are mainly influenced by atherosclerotic process, however, in NSTE-ACS, structural-functional status of myocardium is of primary significance, and in STE-ACS – the degree of manifestation of resorptive-necrotic syndrome.