Abstract
DNA methylation refers to the use of S-adenosylmethionine as a methyl donor (SAM), in the role of DNA methyltransferases (DNMT), the methyl group added 5-methylcytosine (5-mC) was formed on the cytosine of 5'terminal CpG dinucleotide. DNA methylation is one of the common epigenetic events, play a key role in the diagnosis and treatment of tumors, increasingly become a hot topic of related tumors. Digestive system tumors is the main cause of cancer-related death worldwide, and there is a lack of early diagnosis. This article provides a brief overview of the relationship between DNA methylation and digestive system malignant tumors. Key words: Digestive system neoplasms; DNA methylation; CpG islands
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