Abstract
Objective The aim of this study was to investigate the relationship between different psoriasis types and thyroid dysfunction. Methods The data of patients diagnosed with psoriasis between January 2013 and October 2018 who underwent thyroid function tests were collected. Free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), thyroid-stimulating hormone (TSH), thyroglobulin antibody (TGAb), and thyroid peroxidase antibody (TPOAb) were measured. The thyroid function of patients with psoriasis vulgaris, pustular psoriasis, erythrodermic psoriasis, and psoriatic arthritis was evaluated, and the differences in hormone levels and antibodies in the pituitary-thyroid axis with psoriasis type were analyzed. Results The data of a total of 468 patients were analyzed in this study. The proportion of normal hormone levels was higher among vulgaris patients (P < 0.001), while the erythrodermic patients were more likely to have decreased FT3 or FT4 but normal TSH (P < 0.001). FT3 levels were lower in pustular patients (P < 0.05), FT4 levels were lower in erythrodermic patients (P < 0.05), and TSH levels were higher in patients with psoriatic arthritis (P < 0.05). TPOAb levels were higher than normal in all patients, but there was no significant difference in the levels of TPOAb and TGAb among 4 types of the patients. Conclusion Psoriasis is related to thyroid dysfunction, especially in patients with atypical psoriasis types. The possibility of complications should be considered in erythrodermic patients.
Highlights
Psoriasis is an inflammatory skin disease that is caused by immune dysfunction, determined by the inheritance of multiple genes, and stimulated by many environmental factors
Cases were classified as psoriasis vulgaris, pustular psoriasis, erythrodermic psoriasis, and psoriatic arthritis based on clinical characteristics and pathological examination [6]
A total of 468 patients were included in this study, including patients with psoriasis vulgaris (n = 300), pustular psoriasis (n = 60), erythrodermic psoriasis (n = 54), and psoriatic arthritis (n = 54)
Summary
Psoriasis is an inflammatory skin disease that is caused by immune dysfunction, determined by the inheritance of multiple genes, and stimulated by many environmental factors. Its prevalence is around 3% worldwide and 0.1–0.5% in China, respectively [1]. This disorder typically affects the skin and joints, but the fingers, toes, and mucous membranes may be involved. Psoriasis is broadly divided into 4 types: psoriasis vulgaris, psoriatic arthritis, pustular psoriasis, and erythrodermic psoriasis, of which psoriasis vulgaris is the most common, followed by psoriatic arthritis. The incidence of pustular psoriasis and erythrodermic psoriasis is relatively low, but serious systemic symptoms can occur, affecting the physical and mental health of patients, as well as their quality of life [2]
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