Relationship between different levels of central venous pressure and blood loss during pediatric living donor liver transplantation

Abstract

Objective To evaluate the relationship between different levels of central venous pressure (CVP) and blood loss during pediatric living donor liver transplantation (LDLT). Methods Pediatric patients underwent LDLT in Renji Hospital from 2006 to August 10, 2016 were retrospectively reviewed.The patients were divided into 2 groups according to the different CVP levels before peritoneum closure: central venous pressure<10 mmHg group (group L) and CVP≥10 mmHg group (group H). The primary outcome measure was intraoperative blood loss.The secondary outcome measures were duration of mechanical ventilation in intensive care unit (ICU), duration of ICU stay, length of postoperative hospital stay, intraoperative blood loss, intraoperative blood transfusion, intraoperative volume of liquid infused, operation time and anesthesia time. Results A total of 442 pediatric patients were enrolled in this study, with 209 cases in group L and 233 cases in group H. Compared with group H, the intraoperative blood loss was significantly decreased, the anesthesia time, operation time and length of postoperative hospital stay were shortened (P 0.05). Conclusion Maintaining intraoperative CVP<10 mmHg can markedly reduce the blood loss during LDLT and is helpful for postoperative recovery in pediatric patients. Key words: Liver Transplantation; Child; Central venous pressure; Blood loss, surgical