Abstract
Psoriasis is a chronic inflammatory and immunologic disease of unknown etiology. It has been found that increased number of dendritic cells(DCs)and effector T-lymphocytes infiltrate skin lesions of psoriasis, indicating that DCs are involved in the inflammatory response in psoriasis. In normal skin, there are mainly three kinds of DCs: epidermal Langerhans cells, dermal myeloid DCs and plasmacytoid DCs. In skin lesions of psoriasis, the three kinds of DCs interact with T cells, keratinocytes and neutrophilic granulocytes, which can induce and aggravate inflammatory responses. In addition, type I interferon secreted by plasmacytoid DCs in a Toll-like receptor-dependent manner can enhance the activation of myeloid DCs and release of inflammatory mediators. Key words: Psoriasis; Dendritic cells; Antigens, CD11c
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