Abstract
Aims: It is now clear that cytokines such as interleukins play a fundamental role in inflammatory processes. Cytokines now offer alternative targets for therapeutic intervention and may be useful as predictive biomarkers of disease. In this study, we aimed to ev aluate the relationship between cytokines andspinal mu opioid receptor expressionduring adjuvant-induced arthritis (AA) in rats. Methodology :AA was induced by a single subcutaneous injection of CFA into the rats � hindpaw. Anti-IL-6 and IL- 10 were adm inistered dailyduring the 21 days of study. Hyperalgesia and edema were assessed on days 0, 3, 7, 14 and 21 by radiant heat and plethysmometer respectively. Spinal mu opioid receptor (MOR) expression was detected by Western blotting. Results: Daily administration of neutralizing doses of anti -IL-6 caused a significant decrease in serum IL-10 level in AA rats, while treatment with anti -IL10 antibody in the AA
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