Relationship between C-Reactive Protein / Albumin Ratio and Coronary Artery Disease Severity in Patients with Chronic Coronary Syndromes

Abstract

Background: Syntax score (SS), which is an angiographic technique used in categorizing the severity of coronary artery disease (CAD), has a significant prognosis in coronary artery disease (CAD) and explain an important information concerning selection of revascularization policy. C-reactive protein (CRP) and albumin are markers of inflammation, and high levels of them are associated with high SS. Aim of the Work: To detect whether baseline CRP to albumin ratio (CAR), an easily available and novel inflammatory indicator, is associated with SS in patients with chronic coronary syndromes. Methodology: This study was carried out on 100 patients having chronic coronary syndromes for whom, a diagnostic coronary angiography was done at Sohag University Cath. Lab unit in the period from January -July 2021. Patients were divided randomly into two equal groups:*Group I, patients having low SS (≤22). *Group II, patients having intermediate-high SS (>22).Results: C-Reactive Protein/Albumin Ratio was significantly higher in patients having intermediate-high SS group (P < .0001). In multivariate regression analysis, CAR was an independent indicator of intermediate-high SS group together with LDL. Conclusion: CAR was more intensely related to the severity of CAD than CRP and albumin alone and was detected to be an independent indicator for intermediate- high SS group.