Abstract
目的 了解正常和下生殖道感染孕妇阴道分泌物白细胞介素8(interleukin-8,IL-8)的水平变化特点与妊娠结局的关系. 方法对下生殖道有霉菌、滴虫、沙眼衣原体、解脲支原体、人型支原体、细菌性阴道病感染或其中一种以上微生物感染的255例观察组孕妇阴道分泌物进行IL-8定量检测及妊娠结局的随访观察,观察组中发生不良妊娠结局的孕妇取胚胎组织和胎盘组织进行病原体及病理检查,下生殖道无上述微生物感染的120例正常孕妇作为对照组. 结果 (1) 观察A组在妊娠早、中、晚期IL-8浓度的平均值分别为(222.9±193.6) ng/L、(320.0±163.9) ng/L、 (423.1±115.9) ng/L,对照组IL-8浓度的平均值分别为(125.0±45.3)ng/L、(269.0±59.5) ng/L、(359.0±107.1) ng/L, 两组比较差异有极显著性(P 800 ng/L的观察B组中用抗生素治疗的孕妇有5.26%(2/38)发生异常妊娠结局, 而未用抗生素治疗的孕妇有78.13%(25/32)发生异常妊娠结局,两组比较差异有极显著性(P<0.001).(3)妊娠结局异常孕妇的胚胎和胎盘组织中检出与宫颈分泌物相同的病原微生物,病理检测有绒毛膜炎性表现. 结论 IL-8水平的监测对早期预测下生殖道感染孕妇发生宫内感染和指导适时有效抗生素治疗,防止异常妊娠结局发生有重要的临床意义。
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