Abstract

Peanut allergy affects up to 3% of children, but the severity of systemic allergic reactions to peanut is variable, and fatal peanut-induced anaphylaxis is rare.1 The factors that determine the severity of allergic reactions to peanut are not clear, although reduced activity of platelet-activating factor acetylhydrolase has been reported.2 Recent murine data suggest that peanut extract activates complement more than other allergenic foods; this complement activation might influence sensitization to peanut or affect the threshold of reactivity, and it might be an important factor in the increased severity of clinical reactions seen with peanut compared with other food allergens.

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