Abstract
BackgroundMicroparticles are procoagulant membrane vesicles that play role in endothelium dysfunction pathogenesis and are increased in hypertension, acute/chronic vascular pathological events. Here; we aimed to compare MPs levels of hypertensive geriatric patients with healthy age-match-patients, discuss its availability as a cardiovascular biomarker and investigate its relationship with other inflammatory markers.MethodsForty seven hypertensive geriatric patients (M/F;15/32) and 47 healthy controls (M/F;19/28) were included in the study. MPs levels were examined functionally through thrombin generation test (TGT) parameters (MPS Lag time, MPS ETP, MPs Peak, MPS start Tail) and compared with CRP, N/L ratio, ALT, GGT, thrombocyte parameters. Decrease in MPS Lag time, increase in MPS ETS and MPs Peak elevation were accepted as tendency to coagulation which meant an increase in number and function of MPs.ResultsNo significant difference was found between 2 groups for MPS tests (MPS Lag time, MPS ETP, MPs Peak, MPS start Tail). Platelet count was significantly higher in hypertensive patient group. There was a negative correlation between age and MPs Peak, MPS Lag time. There was a positive correlation between CRP and MPS ETP, MPs Peak values.ConclusionsOur present findings might help to understand the hemostasis via TGT parameters, in the elderly. Contribution of MPs to thrombosis tendency seen with aging and increased number of circulating MPs caused by hypertensive endothelial dysfunction must be taken into consideration. MPs might be accepted as vascular inflammation and damage markers and used as follow up tools of medical treatment of vascular inflammation-related diseases.
Highlights
Microparticles are procoagulant membrane vesicles that play role in endothelium dysfunction pathogenesis and are increased in hypertension, acute/chronic vascular pathological events
Aging causes changes in thrombocyte function, increase in coagulation proteins and fibrinolysis dysfunction which result in a change in vascular, hemostatic and coagulation system [7,8,9]
It is shown that endothelial derived MPs (EMPs) are decreased but MPs procoagulant activity persisted in aging [13]
Summary
Microparticles are procoagulant membrane vesicles that play role in endothelium dysfunction pathogenesis and are increased in hypertension, acute/chronic vascular pathological events. Microparticles (MPs) which are called microvesicles are procoagulant membrane vesicles that are directly secreted from cell membrane by exocytic budding when apoptosis and cellular activation occur [1, 2]. They don’t have a nucleus but other cytoplasmic parts and their size is 0.1–1.0 μm [3]. They are secreted from thrombocyte, leukocyte and endothelium They play roles in endothelium dysfunction pathogenesis and are increased in. It is shown that endothelial derived MPs (EMPs) are decreased but MPs procoagulant activity persisted in aging [13]
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