Relationship Between Chordin Like-1 Protein Level and Patients with Pulmonary Arterial Hypertension Disease

Abstract

Pulmonary arterial hypertension (PAH) is a serene executioner, which can incite irreversible changes in pneumonic vascular structure and point of confinement, developing pulmonary vascular resistance (PVR), right ventricular disappointment, and death. Background and Objective: This study was done at the Cardiac Centre of Al-Sader Medical City Hospital in Al-Najaf Al-Ashraf province for the period from December 2016 to May 2017 to investigate the level of biomarker of Chordinlike-1for patients with pulmonary arterial hypertension as predictive indicators of the disease for detection, diagnosis and early treatment of patients. Materials and Methods: The study was applied on 88 people aged 30-69 years; 67 patients group with pulmonary arterial hypertension (PAH) and 21 healthy group. The group of patients was divided into subgroups based on gender, age, body mass index (BMI), waist circumference, smokers and non-smokers,type of primary and secondary arterial hypertension, types of secondary arterial hypertension, and disease grade. The healthy group was divided according to gender and age. Results The study emerged a significant decrease (p less than 0.05) in the level of Chordin like-1 in the group of pulmonary arterial hypertension patients compared to the healthy group, the female group compared to the males, the age group at the age of 30 to 69, Secondary compared with a primary and the disease grade group was found that sever lower than moderate and mild.While the level of Chordin like-1 in the healthy group divided by gender and age have no significant differences.The study produced that in comparing secondary PAH types, there was a significant decrease (p less than 0.05) in the level of Chordin like-1 for both COPD and Left Heart Disease systolic dysfunction or diastolic dysfunction (LHD sys or dia) compared with Valvular, Congenital, and Pulmonary embolism. While there was no significant difference in the level of Chordin like-1between Valvular, congenital and pulmonary embolism. The study revealed no significant difference in the level of Chordin like-1 for the patients group of pulmonary arterial hypertension divided according to BMI group (normal weight, overweight, obese weight), waist circumference group (70-80 cm, 81-90 cm, 91-100 cm, 101-110 cm, 111-120 cm) and the group of smokers compared to non-smokers. conclusion: The biomarker Chordin like-1consider cautioning sign as a prognostic marker for determination PAH patients.