Relationship Between Cholinesterase Inhibitor Insecticides In Human Blood And Insecticides Residues In Drinking Water In Mansoura City- Egypt

Abstract

Pesticides are classified into four major groups; insecticides, herbicides, rodenticides and fungicides. Insecticides poisoning is one of the most common poisoning affecting our population. The study investigates the relationship between cholinesterase inhibitor insecticides in human blood and insecticides residues in drinking water in Mansoura city. Sixty patients suffering from insecticides poisoning admitted to Emergency Hospital Mansoura University- Egypt in March 2005, were included in this study. Blood samples were collected from these patients. The studied patients and their relatives were asked to obtain water samples of their drinking water from the localities where they live. Thirty drinking water samples were collected. Blood and water samples were extracted using Liquid-liquid extraction technique (LLE) and analyzed for pesticides using Gas Chromatography-Mass Selective Detector (GC-MSD). In addition, blood samples were analyzed for plasma pseudo-cholinesterase level (PChE) and red blood cells acetyl cholinesterase activity (AChE). The analysis of drinking water and blood samples revealed organophosphorous (Mevinphos) and organochlorine (Aldrin) insecticides. Moderate insecticides poisoning was more common among the studied groups (65.0%) compared to mild and severe poisoning. The peak incidence of poisoning was in the age group from 20-30 years (46.67%), followed by the age group from 10-20 years (43.33%). There was a female sex predominance among the poisoned patients (56.67%). There was a negative correlation between the severity of poisoning and each of PChE levels and AChE activity % being lowest (p<0.001) in severe poisoning compared to moderate and mild poisoning.