Abstract
This study examined the relationship between inhibition of cholinesterase activity (CA) and thermoregulatory response in the rat following exposure to the organophosphate (OP), diisopropyl fluorophosphate (DFP). Male Long-Evans rats were injected with DFP dissolved in peanut oil in doses ranging from 0 to 1.5 mg kg (s.c.). Colonie (T col) and tail skin temperature (T tail) were recorded at 0, 1,2 and 3 h post-injection. At 3 h post-injection the rat was sacrificed and a blood sample was taken by cardiac puncture and analyzed for CA. There was a biphasic dose effect of DFP on T col with slight but significant elevation in T col in the dose range of 0.01–0.5 mg/kg and a significant depression in T col at doses of 1.0 and 1.5 mg/kg. There was a dose-dependent fall in CA with DFP administration in the erythrocyte, plasma, and whole blood fractions. Hypothermia was associated with 80–87% inhibition in CA, whereas the elevation in T col was associated with 20–70% inhibition in CA. DFP also elicited significant elevations in T tail. Overall, the data fail to demonstrate any clear relationship between inhibition of blood CA and thermoregulatory response following exposure to DFP. However, the elevation in T col following relatively low doses of DFP may be of relevance to the frequently reported symptom of fever in humans exposed to OP agents.
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