Relationship between change rate of rSO2 and early postoperative cognitive function during laparoscopic surgery in elderly patients

Abstract

Objective To evaluate the relationship between the change rate of regional cerebral oxygen saturation (rSO2) and early postoperative cognitive function during laparoscopic surgery in elderly patients. Methods Fifty American Society of Anesthesiologists physical status Ⅰ-Ⅱ patients, aged 65-80 yr, scheduled for elective laparoscopic radical resection for colorectal cancer under general anesthesia, were enrolled in this study.rSO2 was recorded at 5 min before anesthesia induction (T0), 5 min after tracheal intubation (T1), 5 min after changing position (T2), 1 h after changing position (T3), 5 min after stopping pneumoperitoneum (T4), and 5 min after changing to supine position at the end of pneumoperitoneum (T5). The change rate of rSO2 was calculated at T3.Mini-Mental State Examination scores were performed at 1 day before surgery and 3 days after surgery.The patients were divided into cognitive disorder group and non-cognitive disorder group. Results Compared with non-cognitive disorder group, rSO2 was significantly increased at T2-5, and the change rate of rSO2 was enlarged in cognitive disorder group (P<0.05). The change rate of intraoperative rSO2 was negatively correlated with Mini-Mental State Examination scores at 3 days after surgery (r=-0.516, P<0.01). Conclusion The increased change rate of rSO2 during laparoscopic surgery may be related to the development of early postoperative cognitive dysfunction in elderly patients. Key words: Aged; Laparoscopy; Brain; Oxygen; Cognition disorders