Relationship between breathing gas mixtures and retinal vessel regulation

Abstract

PurposeIt is known that components of oxygen transport pathway communicate with vascular endothelium. However, oxygen‐induced vessel constriction results in a decrease in retinal blood flow. Because the delivery and removal of metabolites and gases is proportional to blood flow, a decrease in blood flow could have deleterious effects. Due to the systemic nature of the endothelium, this should be taken into account wherever breathing gas mixture is changed (anesthesia). This work aims to clarify how the constriction of the retinal vessels is modulated by breathing gas mixtures using dynamic vessel analysis (DVA).MethodsThe baseline diameters of 15 volunteers (9 m, 26.3 ± 3.3 y) were measured using DVA (Imedos Systems GmbH). We investigated four primary vessel segments (superior as well as inferior temporal artery (STa/ITa) and vein (STv/ITv). For each volunteer, the DVA was performed 5 times (each: duration 15 min [1 min baseline, 8 min gas mixture, 6 min recovery], rest period: 10 min) in a randomized order using different gas mixtures (21%, 30%, 40%, 50%, 60% O2) provided by a ventilator (Bellavista 1000, imtmedical AG). For statistical analysis, the t‐test and the Wilcoxon test for paired samples (Bonferroni corrected) were used.ResultsFor all vessel segments, a stronger constriction could be observed with an increase in the oxygen concentration. The maximum constriction was always measured at the end of the 8 min period. Here, when comparing the constriction values of the 21% O2 concentration, already the 30% O2 concentration showed significant changes (30%/40%/50%/60% STa: p = 0.002/0.001/0.000/0.000, ITa: p = 0.001/0.001/0.001/0.000, STv: p = 0.000/0.000/0.000/0.000, ITv: p = 0.001/0.000/0.000/0.000).ConclusionsThe presented work revealed that even a small change in breathing gas mixture causes a significant change in vessel constriction. These effect is not only to be expected at the retina, but also in the brain as an example. This should be taken into account, amongst others, for longer anesthesia.