Relationship between brain lutein (L) and zeaxanthin (Z) and retinal L and Z in humans

Abstract

BackgroundL and Z preferentially accumulate in the neural retina, as macular pigment (MP), and also in the brain tissue. Given the predominance of L in adult and pediatric brain tissues and the significant association of L with cognitive health in older adults, it is imperative to have a tool to assess brain L and Z status.PurposeTo evaluate the correlation between brain L and Z and retinal L and Z in humans.MethodsVoluntarily donated brain tissue and matched retina were obtained from a brain bank which adheres to strict consent and confidentiality procedures. Decedents were men and women aged >50 y who either had normal cognitive function or Alzheimer's disease. Tissues were analyzed using standard lipid extractions and reverse phase HPLC. SPSS version 19 was used for statistical analyses.ResultsTotal L and Z in the occipital cortex of the brain was positively related (r=0.865, n=3) to total L and Z in the retina in a bivariate analysis. Due to small sample size the ‘p’ value was non‐significant. Tissues (occipital cortex, hippocampus and retina) from seven more decedents are currently being analyzed.ConclusionsAs MP can be measured non‐invasively in humans, it could be used as a biomarker to assess brain L and Z status.Support: USDA# 1950‐51000‐065‐08S, DSM NutritionalsGrant Funding Source : USDA# 1950‐51000‐065‐08S, DSM Nutritionals