Relationship between bone mineral density and hip fracture type in patients with Parkinson disease

Abstract

Objective To investigate the association between bone mineral density (BMD) and hip fracture type in patients with Parkinson disease (PD). Methods From January 2010 through April 2014, 43 patients with PD were treated at our department for hip fractures. They were 14 males and 29 females, with an average age of 79.3±11.4 years and an average BMD of 21.9±3.9 kg/m2. Their PD course averaged 5.4±4.8 years. Of them, 26 had femoral neck fracture and 17 femoral intertrochanteric fracture. The BMDs at 5 regions (neck, trochanter, inter-trochanter, whole hip and Ward) were compared between femoral neck fractures and femoral intertrochanteric fractures. Multinomial logistic regression was conducted to analyze the correlation between BMD and hip fracture type. Results The BMDs at the regions of trochanter, inter-trochanter and whole hip in femoral neck fractures (0.636±0.147 g/m2, 0.751±0.113 g/m2 and 0.787±0.139 g/m2) were significantly higher than those in femoral intertrochanteric fractures (0.573±0.125 g/m2, 0.602±0.127 g/m2 and 0.672±0.121 g/m2) (P 0.05). Logistic regression analysis showed that the BMDs at the regions of trochanter, inter-trochanter and whole hip were associated with the fracture type (P < 0.05). An increase of one unit of BMD at the regions of trochanter, inter-trochanter and whole hip caused the risk of femoral intertrochanteric fracture to decrease to 0.21, 0.37 and 0.36 of that of femoral neck fracture. Conclusion For patients with PD, the BMDs at the regions of trochanter, inter-trochanter and whole hip in femoral neck fractures are remarkably higher than those in femoral intertrochanteric fractures. Key words: Parkinson disease; Hip fractures; Bone density; Osteoporosis