Abstract
Purpose The purpose of this study was to investigate the association between body roundness index (BRI) and type 2 diabetes (T2DM) in each sex, explore the dose-response relationship between them, and evaluate the predictive value of BRI for T2DM. Materials and Methods A retrospective cohort study was performed on 15,464 Japanese patients at the Murakami Memorial Hospital. Data on anthropometric indices and biochemical parameters were obtained. Multivariate Cox regression models were used to estimate the hazard ratios (HRs) of incident T2DM associated with BRI. Dose-response relationships were evaluated using a smoothing function analysis and the threshold effect. Receiver operating characteristic curves were used to evaluate and compare the predictive values of BRI, body mass index (BMI), and waist circumference (WC) for T2DM. Results During a median 5.4-year follow-up period, 373 subjects were diagnosed with T2DM. After adjusting for age, alcohol intake, smoking status, fatty liver, systolic blood pressure, fasting plasma glucose, glycated hemoglobin, high-density lipoprotein cholesterol, triglycerides, and total cholesterol, the relationship between BRI and T2DM was linear in women (HR (95% CI) for BRI Z score = 1.48 (1.26,1.74)) and curvilinear in men (HR (95% CI) on the left and right of the inflection point = 0.70 (0.44, 1.10) and 1.46 (1.27, 1.67), respectively). Compared with BMI (area under the curve (AUC) = 0.684; p < 0.001) and WC (AUC = 0.700; p=0.007), BRI was the strongest predictor of T2DM in men (AUC = 0.715). Similarly, the AUC of BRI was larger than that of BMI (AUC = 0.757; p=0.966) and WC (AUC = 0.733; p=0.015) in women. Conclusions BRI was positively linearly associated with an elevated risk of incident T2DM in women. In men, the relationship between BRI and T2DM was J-shaped. BRI is an effective indicator of predicting T2DM. Its discriminatory power was higher than that of BMI and WC in both sexes.
Highlights
In 2019, the International Diabetes Federation reported that 463 million people aged 20–79 years were diagnosed with diabetes mellitus, and type 2 diabetes mellitus (T2DM) was the most common [1]
We aimed to evaluate the association between body roundness index (BRI) and T2DM in Japanese men and women, explore the dose-response relationship, and investigate whether BRI has a superior predictive value for T2DM than traditional anthropometric indices such as Body mass index (BMI) and waist circumference (WC)
373 subjects were diagnosed with T2DM after a median 5.4-year follow-up period
Summary
In 2019, the International Diabetes Federation reported that 463 million people aged 20–79 years were diagnosed with diabetes mellitus, and type 2 diabetes mellitus (T2DM) was the most common [1]. Obesity is a known risk factor for T2DM [3]. E relationship between BMI and T2DM has already been described by several studies [6, 7]. BRI is an independent risk factor for and a predictor of T2DM incidence [15, 16]. To International Journal of Endocrinology the best of our knowledge, the dose-response relationship between BRI and T2DM has not been elaborated to date. It remains controversial whether BRI is a better anthropometric indicator than BMI for predicting the occurrence of diabetes [13, 14, 16]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
