Relationship between BMP2/9 Levels and Spinal Function and Quality of Life in Patients with Severe Scoliosis after PVCR.

Abstract

Objective To explore the relationship between (bone fusion associated protein) bone morphogenetic protein (BMP)2 and BMP9 and spinal function and quality of life in patients with severe scoliosis after posterior vertebral column resection (PVCR). Methods 78 cases of severe scoliosis treated with PVCR surgery in our hospital from January 2015 to April 2018 were selected and set as the observation group, and 80 health examiners in the same period were selected and set as the control group. The ELISA method was used to detect the levels of BMP2 and BMP9 in the two groups. Also, the relationship between the recovery of spinal function, quality of life, and serum BMP2 and BMP9 in the observation group was analyzed. The receiver operating characteristic curve was used to evaluate the predictive value of BMP2 and BMP9 for complications after PVCR. Results One month after PVCR, the serum BMP2 and BMP9 levels of patients with severe scoliosis were higher than those of healthy people (P < 0.05). One year after PVCR, Pearson correlation analysis showed that serum levels of BMP2 and BMP9 in patients with scoliosis were positively correlated with ODI scores (r = 0.778, P < 0.001; r = 0.746, P < 0.001), SRS-22 scores (r = 0.758, P < 0.001; r = 0.722, P < 0.001), and Cobb angle correction rate (r = 0.838, P < 0.001; r = 0.802, P < 0.001). Conclusion The levels of BMP2 and BMP9 of patients with scoliosis after PVCR are higher than those of healthy people. After 1-year follow-up, the patients' serum BMP2 and BMP9 levels were positively correlated with spinal function recovery, quality of life, and surgical efficacy. Among them, BMP2 and BMP9 had the highest correlation with PVCR surgical efficacy. Paying attention to the serum BMP2 and BMP9 levels of patients with scoliosis has certain clinical significance.