Relationship between blood levels of visfatin and glycolipid metabolism and mild cognitive impairment in patients with type 2 diabetes

Abstract

Objective To explore the relationship between blood levels of visfatin and glycolipid metabolism and mild cognitive impairment (MCI) in patients with type 2 diabetes (T2DM). Methods From February 2016 to January 2017, a total of 91 patients with T2DM were recruited as investigation objects. Cognitive function was measured by Montreal Cognitive Assessment (MoCA), and fasting serum was collected to determine the relevant laboratory indexes. Results In the 91 patients, 50 cases developed MCI. Compared to non-MCI group, MCI group had significant difference in age, total cholesterol, insulin, insulin resistance index, visfatin, MoCA score and diabetic retinopathy (P<0.05). Pearson correlation analysis showed that the MoCA score was negatively correlated with visfatin and insulin resistance index (P<0.05). Further logistic regression analysis showed that age, diabetic retinopathy, insulin resistance index and visfatin were independent risk factors for MCI in T2DM patients. Conclusions MCI in T2DM patients increases with the increasing of elder, diabetic retinopathy, insulin resistance index, and visfatin. Key words: Nicotinamide phosphoribosyltransferase/ME; Glycolipids/ME; Diabetes mellitus, type 2/CO/ME; Cognition disorders/CO/ME