Relationship between Blood Lead Levels and Nitric Oxide (NO) Levels in Preeclampsia

Abstract

Objective: This study aims to determine the relationship between blood lead levels and NO levels in preeclampsia. Methods: This research applied analytical survey research with a cross-sectional design. Moreover, the samples were 99 pregnant women, 33 with normal pregnancies, 33 with preeclampsia living >10km from Semen Padang factory, and 33 with preeclampsia who lived ≤10km from Semen Padang factory. Spearman correlation test and logistic regression analysis is used for data analysis. Result: The result of this study shows that the blood lead level median in preeclampsia ≤10km is 26.23 g/dL, and the lead level median in preeclampsia >10km is 23.52 g/dL. Meanwhile, the NO level median in preeclampsia ≤10km is 22.50µmol/L and NO level median in preeclampsia >10km is 28.00µmol/L. There is a relationship between blood lead levels and NO levels in preeclampsia ≤10km, with r-value = -0.601 and p-value <0.001, in preeclampsia >10km, there is no relationship with p-value >0.500 and the strength of the correlation is fragile. In addition, the results of multivariate analysis of reduced levels of NO in preeclampsia with high blood lead levels are two times compared to preeclampsia with normal blood lead levels with 95% CI (0.652-6.362) after being controlled by distance of residence, smoking status and living environment variables. Conclusion: there is a relationship between blood lead levels and NO levels in preeclampsia.