Abstract
The current work aims to study the bioaccumulation of aluminum (Al) ions in the tissues of male rats, as well as to shed light on the relationship of that accumulation to the ionic content of some elements in these tissues. To achieve this goal, the rats were divided into two groups, the first group (control) was intranasal instilled with deionized water, whereas the second was given a single acute dose of nanoalumina (LD25 at 96h that's equivalent to 1.66 g /kg b. wt.). After 24 hours, compared to the control group, the bioaccumulation of Al ions in the liver, kidneys, spleen, lungs, and brain had a significant increase. The bioaccumulation of Al ions in all tissues was associated with a significant decrease in the ionic content of iron, zinc, and copper. On the contrary, the ionic content of calcium was increased. The Al accumulated in most tissues has exhibited an inverse significant relationship with the levels of Fe, Zn, and Cu but the Ca ions showed a positive relationship. In conclusion, the bioaccumulation of Al ions caused a significant effect on the most tissues ionic content of Fe, Zn, Cu, and Ca in male rats.
Highlights
The rise of nanotechnology has become an essential component of everyday human life and our environment [1]
The average levels of Al ions in the kidneys of the group I were markedly lesser than its concentration in the brain, and this Al content was significantly greater than its level in the spleen and lungs (Table 1)
In addition to the above, it was evident from the results that the significant bioaccumulation of aluminum in the rats of the second group was accompanied by a sharp and significant decrease in the ionic content of iron, zinc, and copper in all the tissues of the studied organs, when compared with their counterparts in the first group, except the spleen copper content didn't differ (Table 1)
Summary
The rise of nanotechnology has become an essential component of everyday human life and our environment [1]. It is established that nanoparticles (NPs) are molecules having a critical dimension of less than 100 nanometer (nm). Due to their size, wide surface area and volume to mass ratio, NPs have specific optical, mechanical, electrical, chemical, and magnetic characteristics that make them more reactive compared to their bulk materials [2]. Nanoparticles represent possible dangers, both medically and environmentally [7] [8] Most of these dangers are due to the high surface to volume ratio, which can make the particles very reactive or catalytic [9]. Copper nanomaterials have been documented to possess toxic effects on the liver and kidney. Cytotoxicity, cell membrane damage, and increased oxidative stress have been developed in various mammalian cell lines as the most common toxic effect of zinc nanoparticles [12]
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