Relationship between behcet's disease and oxidant and antioxidant markers

Abstract

Behcet’s disease is known as a chronic and inflammatory vasculitis with multiple system and organ involvement. In this study, we aimed to evaluate the relationship between BD and oxidative stress by evaluating the total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) in healthy control group and patients with Behcet’s disease (BD). Materials and Methods: Study groups were composed of BD patients (n = 57) and healthy controls (n = 54). Serum total TAS, TOS, (OSI) and serum lipid levels were measured by photometric method. All measurements were made on Beckman Coulter AU5800 Series (Japan). OSI was determined by the TOS / TAS ratio. Serum TAS levels in BD were lower than the healthy controls (p = 0.039). Serum levels of TOS, OSI and lipids did not differ significantly in BD patients compared to healthy controls. Also, the sensitivity of TAS for BD was high (0.825). Low TAS levels can play an important role in the etiopathology of BD. Increasing serum TAS levels may be beneficial for the clinical process. More studies are needed in this regard.