Abstract
There are, to our knowledge, no histologic data correlating aneurysm volume with histologic healing following coil embolization of aneurysms. We report a retrospective study comparing histologic outcome with aneurysm volume in elastase-induced aneurysms in rabbits. Aneurysm volume and histologic healing after coil embolization were retrospectively analyzed in 37 elastase-induced aneurysms in rabbits. Aneurysm dimensions (including neck, width, height, and volume) were measured and calculated. Packing density (PD) was calculated. Angiographic results were evaluated as recurrence, stable, and progressive occlusion. An ordinal grading system was used to evaluate the histologic healing after embolization. Correlations among aneurysm volume, PD, and histologic healing were analyzed by conducting linear regression analysis. For all the aneurysms in this study, mean aneurysm volume was 80.8 +/- 48.6 mm(3) (from 22 to 192 mm(3)), mean PD was 30.4 +/- 8.3% (from 17% to 49%), and mean histologic score was 6.1 +/- 2.0 (from 0.5 to 9.5), respectively. Correlations between aneurysm volume and PD, aneurysm volume and histologic healing, and aneurysm packing and histologic healing were all significant (P < .01). In this study, aneurysms with smaller volumes and higher PD were associated with the most complete histologic healing. The incomplete healing seen in the larger aneurysms is consistent with the higher incidence of recurrences after endovascular treatment that is seen in large human aneurysms.
Highlights
AND PURPOSE: There are, to our knowledge, no histologic data correlating aneurysm volume with histologic healing following coil embolization of aneurysms
The incomplete healing seen in the larger aneurysms is consistent with the higher incidence of recurrences after endovascular treatment that is seen in large human aneurysms
Endovascular coil embolization has been widely used as an effective method for the treatment of intracranial aneurysms.[1,2,3,4,5]
Summary
Aneurysm volume and histologic healing after coil embolization were retrospectively analyzed in 37 elastase-induced aneurysms in rabbits. Aneurysm dimensions (including neck, width, height, and volume) were measured and calculated. Angiographic results were evaluated as recurrence, stable, and progressive occlusion. An ordinal grading system was used to evaluate the histologic healing after embolization. Correlations among aneurysm volume, PD, and histologic healing were analyzed by conducting linear regression analysis. Aneurysm Creation Thirty-seven embolized aneurysms in New Zealand white rabbits (body weight, 3– 4 kg) were retrospectively analyzed in this study. The Institutional Animal Care and Use Committee at this institution approved all procedures. Detailed procedures for aneurysm creation have been described elsewhere.[11] Briefly, the rabbits were anesthetized with an intramuscular injection of ketamine, xylazine, and acepromazine (75, 5, and 1 mg/kg, respectively). A 5F sheath (Cordis Endovascular, Miami Lakes, Fla) was advanced retrograde in the right
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