Relationship between Air Pollution and Hospital Admissions for Chronic Obstructive Pulmonary Disease in Changchun, China: A Season-Stratified Case-Cross Study.

Ye Ju,Huibo Li,Shuang Liu,Xinli Ma,Xinrong Guo,A Liya,Vishwaraj Sontake

doi:10.1155/2021/3240785

Abstract

Background This study aimed to explore the relationship between air pollution and hospital admissions for COPD in Changchun, a northeast city of China, in different seasons. Methods The data on a total of 1,733 hospitalized patients living in Changchun with acute exacerbation of COPD from September 2013 to April 2018 were collected from a comprehensive 3A hospital of Changchun. Daily average concentrations of PM2.5, PM10, SO2, NO2, CO, and O3 were collected from the Department of Ecology and Environment of Jilin Province. The conditional logistic regression model was adopted to analyze the effect of air pollutant concentration on the number of hospitalized patients with COPD in different seasons. Results The maximum OR value for most air pollutants emitted in spring was on lag day 4, in summer and autumn on lag day 3, and in winter on lag day 2. In spring, SO2 and NO2 were entered into the regression equation, and the OR (95%CI) was 0.992 (0.986–0.998) and 1.009 (1.002–1.017); in autumn, PM2.5, PM10, and SO2 were entered into the regression equation, and the OR (95%CI) was 1.005 (1.000–1.011), 0.995 (0.991–1.000), and 1.006 (1.001–1.011), respectively; and in winter, PM2.5 and PM10 were entered into the regression equation, and the OR (95%CI) was 1.008 (1.002–1.015) and 0.994 (0.988–0.999), respectively. Conclusion The relationship between air pollution and hospital admission for COPD in Northeast China varies with different seasons. In spring, NO2 is likely to be the major risk factor for hospital admissions for COPD; in autumn, PM2.5 and SO2 are the major risk factors; and in winter, PM2.5 is the major risk factor.

Highlights

In the past two decades, chronic obstructive pulmonary disease (COPD) has been a major cause of global mortality and morbidity and has produced an enormous burden on patients and the healthcare system [1, 2]
In China, the incidence of chronic obstructive pulmonary disease (COPD) is higher in the northeastern area than in other areas. is study aims to explore the relationship between air pollution and hospital admissions for COPD in Changchun, a northeast city of China, during different seasons since few studies are available about this specific relationship
Data on Hospitalized COPD Patients. e data on a total of 1,733 hospitalized patients living in Changchun with acute exacerbation of COPD (Disease code: J44.51) (AECOPD) from September 2013 to April 2018 were collected from a comprehensive 3A hospital in Changchun, China. e data on COPD from this hospital are representative of the status of hospital admission for COPD in Changchun since the Department of Respiratory Diseases of this hospital is a National Key Discipline and has the largest number of hospital visits for COPD each year and an admittance rate of over 40% of the COPD cases in Changchun

Summary

Introduction

In the past two decades, chronic obstructive pulmonary disease (COPD) has been a major cause of global mortality and morbidity and has produced an enormous burden on patients and the healthcare system [1, 2]. Few studies have reported the association of air pollution with hospital admissions for COPD in the northeast of China. Erefore, only newly diagnosed and admitted patients with AECOPD were included in the present study to determine the relationship between seasonal air pollutants with subsequent admissions to the hospital for AECOPD. A conditional logistic regression model, a more appropriate analysis method, was adopted to explore the relationship between air pollution and hospital admissions for AECOPD in Changchun in different seasons. Is study is of great significance for the prevention and control of the acute aggravation of COPD caused by air pollution in different seasons in cold areas. Is study aims to explore the relationship between air pollution and hospital admissions for COPD in Changchun, a northeast city of China, during different seasons since few studies are available about this specific relationship In China, the incidence of chronic obstructive pulmonary disease (COPD) is higher in the northeastern area than in other areas. is study aims to explore the relationship between air pollution and hospital admissions for COPD in Changchun, a northeast city of China, during different seasons since few studies are available about this specific relationship

Materials and Methods

Results

Discussion