Abstract
Δ9-Tetrahydrocannabinol (THC) induces a characteristic mouse-killing behavior (muricide) in rats (1). The neural mechanism underlying this abnormal behavior is not clearly understood, although some workers have shown that the metabolism of noradrenaline (NA) or serotonin (5HT) in rat brain is influenced by a single administration of THC (2, 3). Bilateral ablations of the olfactory bulb (OB) of the rat were shown to induce muricide (4), suggesting that the OB plays an important role in the manifestation of muricide. Effects of THC on the metabolism of monoamines in the OB have apparently not been reported, although there are numerous papers on THC and the metabolism of monoamines in the whole brain.
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