RELATIONSHIP BETWEEN 25(OH) D LEVELS AND DYSBIOSIS IN CHILDREN - SYSTEMATIC REVIEW

Abstract

Objective: We systematically analyzed the relationship between 25(OH)D serum levels and intestinal dysbiosis in children. Methods: The following databases were systematically searched: Pubmed, Embase, Lilacs, Scopus, Ebsco, and Cochrane. Two reviewers independently examined the studies, collected data, assessed the risk of bias, and ranked the levels of evidence for each outcome in the studies. The pre-specified parameters of interest were 25(OH)D serum levels; sex and intestinal dysbiosis. We only included data from peer-reviewed articles in our analyses. Results: In our primary analysis, there was a positive trend between serum 25(OH)D <20 ng/ml and intestinal dysbiosis, this result should be interpreted with caution. In this systematic review, we identified two observational studies (n=330) with poor quality evidence in which insufficient serum levels of 25(OH)D showed a direct relationship with the occurrence of intestinal dysbiosis, the relationship of intestinal dysbiosis with sufficient levels of Vitamin D is not based on solid evidence. Conclusions: We await the results of ongoing studies to determine this effectiveness.