Relationship analysis of the miR-196a2 polymorphism (rs11614913) with colorectal cancer risk in southern Khorasan, eastern Iran

Abstract

BackgroundIt has been considered that colorectal cancer (CRC) is the fourth most common cause of cancer death with multifactorial characteristics and genetic precedent can provide a comprehensive sight to its etiology. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs /miRs) sequence are considered as prognostic markers with high specify for CRC detection and prevention. Recent researches have indicated that rs11614913 is the most common SNP related to the vulnerability to many of the cancers. This case-control study aims to quantify the correlation between rs11614913 in miR-196a2 and CRC in southeast Iranian population. MethodsTo identify the role of rs11614913 SNP in susceptibility to CRC, this case-control study is done on CRC patients (n = 52) and healthy persons (n = 120) of the same organization with a uniform gender and age dispensation compared to CRC patients and no prior background of any kind of cancer by PCR-RFLP technique. Statistical analysis is carried out utilizing SPSS (version 16). ResultsAfter the comparison of genotype and allele distribution of this SNP among case and control groups, it has not shown any statistically significant findings (P > 0.05). ConclusionWe have not discovered statistically significant association between rs11614913 polymorphism in miR-196a2 and the risk of CRC in the southeast Iranian society.