Relationship analysis of serum CA19-9, CEA, CA125 and sICAM-1 with the diagnosis valuation and tumor metastasis of pancreatic cancer

Abstract

Objective The present research aimed to explore the relationship of serum CA19-9, CEA, CA125 and sICAM-1 concentration with the diagnosis valuation and tumor metastasis of pancreatic cancer. Methods Ninety pancreatic cancer patients in First Affiliated Hospital of Hebei North University from January 2014 to December 2016 were enrolled in this study. The concentrations of serum CA19-9, CEA, CA125 and sICAM-1 were assayed in different stage of pancreatic cancer patients. The concentrations of these parameters were also detected in metastasis patients and non-metastasis patients.In the same period, 90 cases of health examination as contrd group.Measurement data were represented as ±s. Comparison between groups was analyed using t test. single-factor analysis of variance (ANOVA) was used for comparison among groups, and the results were compared by F test. The correlation analysis was performed by spearman method. Results The results showed that CA19-9/β-actin(control group and Ⅰ/Ⅱ/Ⅲ/Ⅳ stage pancreatic cancer were 0.25±0.03, 0.27±0.04, 0.31±0.06, 0.38±0.09, 0.68±0.10, respectively), CEA/β-actin(control group and Ⅰ/Ⅱ/Ⅲ/Ⅳ stage pancreatic cancer were 0.29±0.07, 0.34±0.08, 0.47±0.09, 0.58±0.12, 0.68±0.14, respectively), CA125/β-actin(control group and Ⅰ/Ⅱ/Ⅲ/Ⅳ stage pancreatic cancer were 0.31±0.05, 0.36±0.07, 0.55±0.13, 0.58±0.14, 0.63±0.14, respectively), sICAM-1/β-actin(control group and Ⅰ/Ⅱ/Ⅲ/Ⅳ stage pancreatic cancer were 0.34±0.05, 0.36±0.08, 0.41±0.08, 0.49±0.10, 0.58±0.12, respectively)were higher in pancreatic cancer than control(P<0.05). The tumor metastasis group was higher than tumor un-metastasis group CA19-9/β-actin(un-metastasis group and metastasis group was 0.36±0.09, 0.58±0.12), CEA/β-actin(un-metastasis group and metastasis group was 0.42±0.09, 0.61±0.14), CA125/β-actin(un-metastasis group and metastasis group was 0.48±0.09, 0.60±0.14), sICAM-1/β-actin(un-metastasis group and metastasis group was 0.42±0.09, 0.52±0.10)(P<0.05). The results showed that CA19-9, CEA, CA125 and sICAM-1 concentrations are positively (r value were 0.832, 0.698, 0.748 and 0.845) with the metastasis of pancreatic cancer patients while negatively with the prognosis (r value were -0.867, -0.832, -0.916 and -0.908) and clinical stage (r value were -0.815, -0.896, -0.798, and 0.912) of pancreatic cancer patients. Conclusion CA19-9, CEA, CA125 and sICAM-1 concentrations are positively related with the metastasis of pancreatic cancer patients while negatively with the clinical stage and prognosis of pancreatic cancer patients. Key words: Pancreatic neoplasms; Neoplasm metastasis; Clinical stage; Carbohydrate antigen; Soluble inter-cellular adhesion molecule-1