Relationship among the expression of chemokine ligand 7, pathological grading and peritumoral edema on magnetic resonance imaging in glioma

Abstract

Objective To investigate the relationship among the expression of chemokine ligand 7 (CCL7), pathological grading and degree of peritumoral edema on magnetic resonance imaging (MRI) in gliomas. Methods The expression of CCL7 in the normal brain tissues and the human glioma tissues was detected by Western blotting. The relationship between the expression of CCL7 and pathological grading, between degree of peritumoral edema on MRI and the pathological grading of the gliomas, and between the expression of CCL7 and the degree of peritumoral edema on MRI in the gliomas was analyzed. Results The CCL7 protein expression was detected in the normal brain tissues and the human glioma tissues, and the CCL7 protein expression level in the high rank ( 0 cases of - , 4 cases of , 9 cases of + , and 16 cases of + + ) was higher than the low rank (3 cases of - , 13 cases of , 6 cases of + , and 0 cases of + + ) (P=0.027). The degree of peritumoral edema on MRI in the gliomas in the high rank ( 0 cases of grade 0, 4 cases of grade 1, 9 cases of grade 2, and 16 cases of grade 3) was higher than that in the low rank (5 cases of grade 0, 13 cases of grade 1, 3 cases of grade 2, and 1 case of grade 3) (P=0.019). Spearman correlation analysis showed that the expression of CCL7 was positively correlated with the degree of peritumoral edema on MRI in gliomas (r=0.940, P=0.031). Conclusion The expression of CCL7 and the degree of peritumoral edema on MRI increase with the rank of gliomas, and the expression of CCL7 and the degree of peritumoral edema on MRI were positively correlated in gliomas. Key words: Glioma; Chemokine ligand 7; Pathological grading; Peritumoral edema