Abstract
Purpose: To determine the association between overweight and high-sensitivity C-reactive protein (hs-CRP) with the odds of cognitive impairment as well as its subtypes based on the Asymptomatic Polyvascular Abnormalities Community (APAC) study in China.Materials and methods: We conducted a cross-sectional analysis of the follow-up data of 2012 from the APAC study. The Chinese version of the MMSE was used as a cognitive screener, and an MMSE score <24 is generally accepted as indicating cognitive impairment. Multivariable logistic regression was used to estimate the interactions of hs-CRP levels with body mass index (BMI) on the effects of cognitive impairment and its subtypes.Results: Three thousand eight hundred seventy-five participants aged 40–90 years (median age 51.64 y) were enrolled in this study, and 1,788 (46.1%) were overweight. Before and after adjusting for confounders, such as age, sex, BMI, education, current smoking, drinking, physical activity, hypertension, hyperlipidemia, diabetes, and hs-CRP, elevated hs-CRP levels were associated with cognitive impairment in normal-weight participants (crude OR: 2.08, 95%CI: 1.28–3.37, p = 0.003; adjusted OR: 2.06, 95%CI: 1.03–4.10, p = 0.04), but not in overweight participants. There was no statistically significant evidence for the interaction between hs-CRP and BMI on any cognitive sub-item.Conclusion: Elevated hs-CRP levels increase the odds of cognitive impairment in normal-weight participants, but not in overweight participants.
Highlights
Cognitive impairment has become an obvious and important public health problem among elderly patients, especially with the increasing trend in longevity of these subjects
Before and after adjusting for confounders, such as age, sex, Body mass index (BMI), education, current smoking, drinking, physical activity, hypertension, hyperlipidemia, diabetes, and hsCRP, elevated High-sensitivity C-reactive protein (hs-CRP) levels were associated with cognitive impairment in normalweight participants, but not in overweight participants
Elevated hs-CRP levels increase the odds of cognitive impairment in normal-weight participants, but not in overweight participants
Summary
Cognitive impairment has become an obvious and important public health problem among elderly patients, especially with the increasing trend in longevity of these subjects. 10– 45% of elderly patients experience some degree of cognitive impairment [1], resulting in increased mortality [2] as well as social and economic burden [3]. This trend has been projected to be more dramatic by 2050, and approximately half of the global distribution of incident cognitive impairment will be in Asia [4]. Some meta-analysis showed that being overweight was positively associated with dementia in middle-aged people, but negatively associated with cognitive impairment in middle- and old-aged people [5]. Body mass index (BMI) has been recognized as the most precise value in the evaluation and classification of body weight
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
