Relationship Among Blood Boron Level, Diabetes Mellitus, Lipid Metabolism, Bone Metabolism and Obesity: Can Boron Be An Efficient Indicator for Metabolic Dissesases?

Ruken Esra Demirdogen

doi:10.36648/1791-809x.14.1.689

Abstract

This study targeted at investigating the possibility of association between blood boron (B) level and charbohydrate and lipid metabolisms and bone structuring metabolites and using B as an indicator of obesity and certain diseases as Diabetes Mellitus type II. 42 patients categorized under control, diabetic and obese diabetic groups of 14 subjects (7 male and 7 female) of different age volunteered in the study. Pronounced negative correlation was observed between serum B level and glucose level of female and male subjects in diabetic (r=-0.653; -0.567) and obese diabetic (r=-0.715; -0.748) and HbA1c levels in diabetic (r=-0.452; -0.367) and obese diabetic (r=-0.648; -0.542) groups but no meaningful relation could be established neither with insulin nor with HDL levels. Triglyceride values showed negative correlation in diabetic female (r=-0.483) and obese diabetic male (r=-0.612) groups and so did total cholesterol in diabetic (r=-0.412; -0.541) and obese diabetic (r=-0.578; -0.674) female and male subjects. Vitamin D levels in diabetic (r=0.350; 0.586) and obese diabetic (r=-0.241; 0.453) female and male subjects showed positive correlation. Findings indicated that B level can be a good indicator of diseases related with carbohydrate, lipid and bone metabolisms.

Highlights

Obesity is a chronic disease arising from the excess amount of energy taken into the body via diet compared to the energy used by the body
In this study targeted at investigating the effect of boron on carbohydrate metabolisms of diabetic and obese diabetic patients
A pronounced negative correlation was found between the glucose and hemoglobin A1c (HbA1c) levels of diabetic and obese diabetic female and male subjects and their serum boron levels

Summary

Introduction

Obesity is a chronic disease arising from the excess amount of energy taken into the body via diet compared to the energy used by the body. Today obesity is an aesthetic problem, It affects all the organs and systems in the body especially the cardiovascular and endocrine system and it is accepted as a sickness which causes various disorders and even morbidity [1]. Word Health Organization reports that today 1.6 billion people are overweight and each year at least 2.8 million people lose their lives because of overweight or obesity [2]. One of the most commonly used method in diagnosis of obesity is Body Mass Index (BMI) [4]. Obesity causes development of Type II DM due to the effect of lypotoxicity, lypolytic response and free fatty acids

Methods

Results

Conclusion