Relations between vitamin D3, total and specific IgE for house dust mites in atopic dermatitis patients

Hassan M Ibrahim,Abd Allah E Mohamed,Ebtihal A Kotop,Mohammed H Hassan,Moustafa A El-Taieb,Osama H Abd-Ellah,Eisa M Hegazy

doi:10.1038/s41598-020-77968-1

Hassan M Ibrahim, Abd Allah E Mohamed + Show 5 more

Open Access

https://doi.org/10.1038/s41598-020-77968-1

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Journal: Scientific Reports	Publication Date: Dec 1, 2020
Citations: 5	License type: open-access

Affiliation: South Valley University, Aswan University

Abstract

Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease. There are a lot of evidences on the importance of vitamin D and house dust mite (HDM) allergens in the etiology and course of AD. The objectives of this study are to evaluate the relation between vitamin D3 level and house dust mites (HDM) Dermatophagoidspecies sensitization in pathogenesis of atopic dermatitis. Cross-sectional design study was conducted on 50 atopic dermatitis patients. Blood analysis were done to determine level of vitamin D3, total IgE by fluorescent immunoassay & specific IgE for HDM (d1, d2) & other inhalant allergens by ELISA test. There was significant high negative correlation with the specific IgE for HDM (r = −0. 62, p < 0.001) and vitamin D3. & there was non-significant minimal negative correlation with the specific IgE and other inhalant allergens (r = − 0.10, p > 0.05). There was a statistically significant relation between level of vitamin D3 and atopic dermatitis severity and sensitization to HDM and other allergens.

Highlights

Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease
Atopic Dermatitis (AD) is a chronic inflammatory skin disease characterized by episodes of severe itching, dry skin and erythematous lesions
In the present study we investigated Vitamin D3, Total and specific IgE for house dust mite (HDM) & its relations to the pathogenesis and the course of AD

Summary

Introduction

Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease. The objectives of this study are to evaluate the relation between vitamin D3 level and house dust mites (HDM) Dermatophagoidspecies sensitization in pathogenesis of atopic dermatitis. Crosssectional design study was conducted on 50 atopic dermatitis patients. There was significant high negative correlation with the specific IgE for HDM & there was non-significant minimal negative correlation with the specific IgE and other inhalant allergens (r = − 0.10, p > 0.05). There was a statistically significant relation between level of vitamin D3 and atopic dermatitis severity and sensitization to HDM and other allergens. Atopic Dermatitis (AD) is a chronic inflammatory skin disease characterized by episodes of severe itching, dry skin and erythematous lesions. In patients with genetic defects in certain genes such as filaggrin gene, environmental stimulations as detergents and soaps lead to decrease in hydration and extracellular lipids in the stratum corneum with subsequent production of antigens and enhancement of inflammation[7]

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