Abstract
The recent experimental studies indicated that zinc deficiency may cause thymus hypoplasia and cellular immune deficiency. This inspired us to investigate the relationship between zinc and lymphocytes in pediatric Hodgkin's disease. The serum zinc levels, total lymphocyte counts, coutaneous reactivities to three intradermal antigens and the invitro lymphoblastic transformation response to PHA were evaluated in 24 children with Hodgkin's disease and 20 control cases. Serum-zinc level was measured by atomic absorption spectrophotometer (Perkin Elmer M 103) in Hodgkin's cases found to be significantly low in all patients, regardless of the clinical stage and histopathological pattern. Our preliminary results also disclosed a relationship between serum zinc levels and the lymphocyte abnormalities in Hodgkin's disease.
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