Abstract

Hyperlipemia of diverse etiology is well correlated with elevation of serum vitamin E level. When the various serum lipid fractions were measured, total lipid ( r = 0.85) and β-lipoprotein ( r = 0.81) gave the best correlations with the vitamin E level. Correlation of serum carotene with the various lipid classes gave lower values. A patient with fat-induced hyperlipemia had enormous elevations of serum vitamin E (up to 27.8 mg/100 ml); almost all of it was found in the chylomicron fraction. This patient provides evidence for Pelkonen's hypothesis: namely, vitamin E is first absorbed in the chylomicron fraction and is later transferred to the (3-lipoprotein fraction, where it is almost exclusively found in normal sera in the post-absorptive state.

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