Relation of Visceral and Subcutaneous Adipose Tissue to Bone Mineral Density in Chinese Women

Ling Wang,Dan Liu,Li Xu,Zhe Guo,Yongbin Su,Yimin Ma,Xiaoguang Cheng,Wei Wang,Qianqian Wang

doi:10.1155/2013/378632

Ling Wang, Dan Liu + Show 7 more

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https://doi.org/10.1155/2013/378632

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Abstract

The relationship between adipose and bone tissues is still being debated. The purpose of our study was to evaluate whether the distribution and volume of abdomen adipose tissue are correlated to trabecular bone mineral density in the lumbar spine. In this cross-sectional study, 320 Chinese women, being divided into two groups according to age ≥55 years and <55 years, were evaluated with quantitative computed tomography (QCT) of the spine to simultaneously evaluate the average trabecular BMD of L2–L4, VAT, and SAT. Possible covariates of height, weight, age, and comorbidities were considered. In the <55-year-old sample, multiple linear regression analyses indicated that VAT volume was negatively correlated to trabecular BMD (P value = 0.0003) and SAT volume had no correlation to trabecular BMD. In contrast, there was no significant correlation between VAT or SAT and BMD in the ≥55-year-old sample. Our results indicate that high VAT volume is associated with low BMD in Chinese women aged <55 years and SAT has no relation with BMD.

Highlights

Low bone mineral density (BMD) has long been established as an important risk factor for hip fracture or lumbar fracture [1]
In the group aged
There was an inverse correlation between average trabecular BMD and visceral adipose tissue (VAT) (r = −0.52, P < 0.0001) (Figure 1), which remained significant after adjustment for age and BMI using multiple liner regression analysis (P = 0.01) (Table 4)

Summary

Introduction

Low bone mineral density (BMD) has long been established as an important risk factor for hip fracture or lumbar fracture [1]. It follows that knowledge of the other factors, such as obesity, smoking, alcohol intake, drugs intake, and longterm bed rest, influencing BMD is crucial for preventing and treating osteoporotic disease. Among these factors, obesity was previously thought to have a positive influence on the maintenance of BMD [2,3,4,5]. Further studies are needed to explore the possible effects of VAT and SAT on BMD

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